Contribution to the Assessing the Anti-inflammatory Effects of Ceratonia siliqua L
| dc.contributor.author | CHERNINE , Ikram | |
| dc.contributor.author | BRIGHET , Kenza | |
| dc.contributor.author | BELAMBRI , Sahra amel | |
| dc.date.accessioned | 2024-11-25T14:21:08Z | |
| dc.date.available | 2024-11-25T14:21:08Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Ceratonia siliqua pods have been extensively utilized in traditional medicine in Algeria and the Mediterranean region due to their therapeutic properties. The aim of this research was to assess the in vivo anti-inflammatory efficacy of Ceratonia siliqua L pods and validate their traditional use through oral administration. Two acute inflammation models and an analgesia test were employed to evaluate the anti-inflammatory potential of the prepared solution. The xylene-induced ear edema test demonstrated that the carob solution significantly reduced or even prevented edema with oral administration. This anti-inflammatory effect was notably superior to that of common anti-inflammatory drugs like aspirin. Additionally, peritonitis induced in rats by intraperitoneal injection of λ-carrageenan (1%) revealed that oral administration of the carob solution led to an 83% reduction in leukocyte recruitment in the peritoneal cavity, a result comparable to the 85% reduction induced by salicylic acid at the same dose. However, the tail immersion test did not yield significant results due to handling issues, as the rats were too agitated to tolerate the immersion of their tails in hot water. Consequently, the findings of this study support the significant anti-inflammatory properties of ceratonia siliqua pods macerated with a hydromethanolic solution, affirming their traditional use in Algerian medicine. | |
| dc.identifier.uri | http://dspace.univ-skikda.dz:4000/handle/123456789/3587 | |
| dc.language.iso | en | |
| dc.publisher | Faculty of Sciences | |
| dc.title | Contribution to the Assessing the Anti-inflammatory Effects of Ceratonia siliqua L | |
| dc.title.alternative | Pharmaceutical Chemistry | |
| dc.type | Master’s Degree Thesis |